2^nd International Conference on Epilepsy & Treatment October 20-21, 2016 Rome, Italy

Biography:

Yo-Tsen Liu earned her MD at National Taiwan University in 2001. After that, she completed her Neurological Residency Training and became a Neurology Consultant at Taipei Veterans General Hospital (TVGH) in 2005. After winning “Studying Abroad Scholarship” supported by Taiwan’s Ministry of Education, she studied her PhD at Institute of Neurology, University College London, London, UK in 2010-2014. She is now a Neurology Consultant at Department of Neurology of TVGH and Associate Professor at National Yang-Ming University, Taiwan. Her academic interests are the applications of next-generation sequencing in diverse neurological diseases, including paroxysmal dyskinesia, epilepsy and neurodegenerative diseases.

Abstract:

Paroxysmal dyskinesia (PD) is a clinically and genetically heterogeneous group of diseases characterized by episodically recurrent involuntary movements and classified into three groups: paroxysmal kinesigenic dyskinesia (PKD), paroxysmal non-kinesigenic dyskinesia (PNKD) and paroxysmal exercise-induced dyskinesia (PED). The breakthrough of genetics of PD was the identification of PRRT2 mutations in 2011. Following this, it has been well recognized that there is increasing genetic and clinical overlaps between PD and other paroxysmal neurologic disorders, including epilepsy, hemiplegic migraine, episodic ataxia and migraine. Advancement in genetics of PD has contributed to well-addressed genotypic-phenotypic correlations of the above diseases, which help greatly in improving the efficiency of genetic diagnosis and thus benefit more treatable patients. The rapidly-accumulated genetic knowledge has also shed light on understandings of the normal functions of the related genes and the underlying pathogenesis how these mutated genes to cause diseases. Furthermore, the reversibility of PD may be the key to unravel the mechanisms of other irreversible neurodegenerative diseases and inspire potential targets of treatment in the future.

Biography:

Nanuli Doreulee has received her PhD from Beritashvili Institute of Physiology. She has completed her Post-doctoral studies at the Brain Research Institute (Moscow) and H. Haine University of Duesseldorf (Germany). She is the Head of Direction of Human and Animal Physiology at Tbilisi State University. She has published more than 20 articles in high impact factor journals in recent years.

Abstract:

Epilepsy is a chronic neurological disease affecting roughly 1-2% of the human population worldwide. Progressive spontaneous recurrent seizures lead to hippocampal neuronal death and cognitive/mental disturbances. The seizure activity during epilepsy decreases the antioxidant defense mechanism in the brain and increases the amount of free radicals, which further induces the oxidative stress. Considering the importance of oxidative stress in epilepsy antioxidant and anti-inflammatory treatments may attenuate or prevent epilepsy-related neurodegenerations. Flavonoids are historically part of the basic human diet and have been identified as powerful antioxidants. Flavonoids permeate the blood-brain barrier and are able to localize in the brain, suggesting that they are candidates for direct neuroprotective and neuromodulative actions. Our previous experiments showed that early postnatal feeding with flavonoids from saperavi has beneficial effects on hippocampal related learning/memory mechanism and this was in correlation with changes in the dynamic of postnatal structural formation of the hippocampus. The aim of the present work was to investigate the effects of early life exposure to flavonoids from saperavi (P7-P15, 25 mg/kg per day) on the electrophysiological properties of the pyramidal neurons in the CA1 region of the hippocampus. In vivo electrophysiological recordings were carried in rats. According to our preliminary data, early postnatal feeding of rats with flavonoids from saperavi increases the threshold for the generation of an electrically induced epileptic activity, and reduces frequency and duration of epileptiform discharges.

Biography:

Layla E Borham is a Professor of Clinical Pharmacology at Cairo and Umm AlQura universities. She received her MSc and MD degrees from Cairo University Medical School. She has been working in Faculty of Medicine, Umm AlQura University, KSA for 15 years. During this period, she carried out a lot of scientific and social serving activities through her publications, scientific committee memberships, lectures and administrative work. In addition, she works in the Ministry of Health hospitals and primary health care centers giving awareness lectures to health care providers and patients. She has been awarded a Golden Prize from Umm AlQura University for her overall services at the university.

Abstract:

Evidence shows that inflammatory and immune processes within the brain might account for the pathophysiology of epilepsy. Therefore, developing new antiepileptic drugs that can modulate seizures through mechanisms other than traditional drugs is required for the treatment of refractory epilepsy. This study aims to determine the relationship between brain inflammation and epilepsy, to examine the contribution of some biochemical parameters involved in brain inflammation, and to address the effect of pharmacological interventions using some anti-inflammatory and immunomodulatory drugs in an experimental epilepsy model. Adult male rats were divided into 7 groups of 20. G1 was the normal, non-treated control. G2 was the epileptic, non-treated group. G3–G7 was treated with celecoxib, methotrexate, azathioprine, dexamethasone and valproate, respectively, for a period of 3 weeks. Induction of status epilepticus (SE) by Li-pilocarpine was performed on groups G2–G7. EEG tracing was conducted, and inflammatory mediators (brain and serum IL-1ß, IL 6, PGE2, HSP70, TGF-β2, and IFNγ) were measured. The induction of SE increased the amplitude and frequency of EEG tracing and inflammatory mediators more than in the normal control group. Treatments of epileptic rats reduced the frequency and amplitude of EEG tracing and significantly decreased the levels of inflammatory mediators in some treated rats compared to G2. These findings demonstrate that some anti-inflammatory and immunomodulatory drugs can lower the frequency and amplitude of seizures and reduce some inflammatory mediators in epilepsy treatments, strengthening the possibility that targeting these

Biography:

Sylvain Haba was born on seventh of October 1963 in Kpoulo (Region N’Zerekore).He got his Admission to Bachelor in 1984, later completed his orientation to school nurses. After that he started his Internship in a medical post at Sèbètèrè Gaoual Prefecture where he went on Remote Training on medical semiology. In 1998 he admitted to the public service test, and later Training in traditional medicine in DR Congo foundation for his Back Guinea led in 2006 for the establishment of the Centre Medico-Spiritual Tradi koumi Talitha (Marc5: 41-42) to (Labe) Guinea 2008 and Transferred to the center in Conakry.

Abstract:

Epilepsy is a neurological disease characterized by abnormal functioning of brain activity. It results in the repetition of unexpected crises and often very brief. These attacks can take many forms and vary in intensity. This long regarded disease as compounds devils. - The Water Devil (it kills the patient in the water as soon as the crisis) - The devil fire (it kills the patient in the fire when the crisis) - The devil upper palms and legs (when the victims climb the palm trees or pick oranges or mangoes) Thanks to modern medicine, she was defined. The causes are usually malaria, meningitis, syphilis, HIV and others. It is processed with plant and animal origin.

Maceration composed of three (3) plants: 1) Newbouldia Leavis. f: 10g Bignoniacée 2) Akeben 5g 3) 5g Balanbilin All packaged in a container placed diluted with one liter of water a day for four days during this 60 days with control of monitoring elements. Decoction made: 1) Raphiostilis bénénien icacinacé 10g 2) V.canne 10g 3) Nauclea latifolia rubiaccé 2g 4) Koyalakele (10g root) All boiled with the viscera of a wild animal. After monitoring elements, recommended that the patient drink 3-5 liters of decoction in the range of one hour (1) which causes vomiting and diarrhea causes but effective against seizures. Nasal Goute: 1) Microglossa pyrifolia 1g sheet 2) Citrus medica fruit juice 1ml 3) Oecophylla smaragdina F: Formicidae (yellow ant 20) 6 nasal costs and deposit 3 times daily for 3 days for a period of three weeks especially in the case of petitmal epilepsy.

An ant nest containing ants, larvae, eggs crushed, roasted, mixed with the seed oil Elaeis guineensis (palmacéea) preserved as pasta and kept in a snail shell

Dosage is a pinch of dough on the tongue and two pinched forehead 3 times daily after meals.

The ban of the recipe:

The mystification for research; The pan used to toast the ants, larvae, eggs and nest must not touch the ground and even the wooden spoon; these instruments were placed on a chair to the ceiling of his house to this is added a small freshwater poison called gbongo in Guerzé (language of my ethnicity)

Biography:

Marija Knezevic Pogancev is a Pediatrician, Neuro-pediatrician, Clinical Neurophysiologist and Epileptologist. She is a full time Professor at University of Novi Sad, School of Medicine and Chief of Department for Developmental Neurology and Epileptology, Child and youth health care Institute of Vojvodina, Novi Sad, Serbia. She is graduated from the Faculty of Medicine, University of Belgrade and Trained in Social Pediatry, Institute for Mother and Child Health Care, Belgrade, Trained in Mental Hygiene, Institute of Mental Health, Belgrade. She did her Master’s degree in Neuro-pediatry, Faculty of Medicine, University of Novi Sad and Specialization in Pediatry, Institute for Mother and Child Health Care, Belgrade. She was trained in Electroencephalography and Neurophysiology, Institute of Mental Health, Belgrade and completed her Sub-specialization in Neurology of Developmental Period, Faculty of Medicine, University of Novi Sad, and Scientist Doctor Degree.

Abstract:

Epilepsy is not a lifelong condition in most patients. However, the decision to withdraw of antiepileptic drugs must be based on a balanced view of the overall risk of seizure relapse, the factors most likely to affect that risk, and the medical, emotional and social implications of antiepileptic drug treatment. It is important to admire patient’s (especially if adolescent) and parent’s fear towards the risk of antiepileptic drug withdrawal. The aim of study was to determine patient and family attitudes towards the fear of antiepileptic drug withdrawal, after 3 years seizure control, and to define the risk of seizure recurrence that adolescents and their parents would accept before discontinuing AED. This research was carried out in the Institute for Child and Youth Health Care of Vojvodina in Novi Sad. During the study, which lasted from 2003 to 2008, a face-to-face interview about fear of AET withdrawal was done during adolescent patient examination. Study population included 150 adolescent patients, without epileptic seizures, using one antiepileptic drug, and 265 of their parents. Accepted risk in general is higher in our adolescent patient’s group than in parent’s group (p<0,05). This risk over 50% seem excessive to all parents.

Biography:

Abstract:

The study was designed to evaluate the optimal dosage use of lamotrigine (LTG), as monotherapy, in the treatment of adults suffering from various types of epilepsy in everyday clinical practice. The method used in this study was to collect the data of all adult patients treated with LTG, as monotherapy, retrospectively. The dosage and efficacy of treatment were evaluated along with side effects and retention rate. The results showed that, out of 188 patients, 68% continued LTG treatment; the mean effective dose was higher in older patients and those with a longer disease duration. To conclude, it may be appropriate to reach a daily LTG dose above 200 mg in adult patients suffering from epilepsy for more than 5 years and are treated with LTG as monotherapy

Biography:

Abbas Alnaji has completed his Degree in Neurosurgery FICMS NS from University of Baghdad 1999. He is interested in research work and have 12 papers published in the field of Surgical Pathology Causations.

Abstract:

I see that the neurons that fires to cause seizures, are sick neurons, so that we have a duty of helping these sick neurons where ever they are, rather than to destroy them, as what happens in epilepsy surgery. I wish from epilepsy surgeons to check for any ineffective microorganism in the identified firing focus in the brain cortex or elsewhere by having this focus for PCR tissue examination for Brucella as I mentioned in my article sent for conference of epilepsy and treatment 2015 USA. It is wise to have a screen for more than Brucella with PCR. Many microorganisms are incremented like Salmonella and many other small intracellular bacteria that we have no help to identify them due to our shortage. After surgeons take this focus as a tiny biopsy (PCR needs very small volume), I say after they take this focus let them do whatever they want, if things go as today. Let us know that we are executing a diseased instead of remedy.