Raili Riikonen
Kuopio University Hospital, Finland
Title: New Developments of Epileptic Syndromes in very young Infants
Biography
Biography: Raili Riikonen
Abstract
Epileptic syndromes of very young infants presented here are the following: Early epileptic encephalopathy or Ohtahara syndrome, migrating partial seizures of infancy and West syndrome (presented in more detail).New advances are the following; 1) Expansion of electro-clinical, radiological and pathological disease spectrum. 2) Explanation for pathogenesis of some of the syndromes. 3) Evidence-based data for pharmacological treatments of West syndrome. 4) Recent results of ICISS study from UK. 4) Enlarged indication for the use of ketogenic diet and surgery. 5) Better known side effects of vigabatrin. New options in pipe-line are rapamycin and anti-inflammatory drugs.Future research should include multi-centric RCT trials with multiple treatment arms, management of relapses, prevention of infantile spams, prevention of visual field defects followed by vigabatrin, understanding of brain maturation, etiology, mechanisms and genetics underlying infantile spasms may facilitate more effective intervention.
