Epilepsy & Treatment

Epilepsy affects around 1 in every 200 children and young people under 18 Children having idiopathic. Epilepsy has 90% chances of getting rid of Epilepsy at their 20’s. Epilepsy is most common in children and adults having age more than 60.

 

Seizure alert devices are useful in letting family members know if a seizure is occurring, especially parents of young children Seizure alert devices are useful in letting family members know if a seizure is occurring, especially parents of young children.

Women with Epilepsy have fewer chances to conceive than in non-epileptic women. For women who want marriage or pregnancy, special consideration is necessary, with the single use of commonly used antiepileptic drugs, the malformation incidence and the stillbirth rate will increase to 2 to 3 times of the general population

Maintaining Ketogenic diet, regular exercise can reduce the risk of Epilepsy, get plenty of sleep during nights and avoid using drugs and alcohol. Epilepsy due to medication can be subsided by discontinuing the medicines, controlling stress, anxiety & other emotional issues can reduce the risk of Epilepsy

About 1 out of 10 people has had a seizure. That means seizures are common, and one day you might need to help someone during or after a seizure. Learn what you can do to keep that person safe until the seizure stops by itself

Sudden unexplained death in epilepsy (SUDEP) accounts for 7–17% of deaths among people with epilepsy. Patients with uncontrolled seizures are at greatest risk for SUDEP, and experiencing tonic-clonic seizures, taking multiple antiepileptic drugs and having coexisting neurologic disease further increase the risk.

If Antiepileptic drugs aren't controlling your seizures and brain surgery isn't suitable for you, there are other procedures that could help

Before modern seizure medicines were developed, people with epilepsy and their doctors looked for a remedy in various herbs and combinations of herbs. Good news is, there are some natural remedies for seizures. Before advanced seizure medications were even discovered, doctors used herbs to treat this condition. Herbs for seizures are still used today because of their impressive effectiveness.

Epilepsy can be treated in a number of ways. One of the most preferred forms of treatment is homeopathy. Homeopathy addresses both the physical symptoms of the disease and the underlying factors triggering it. Another big advantage of homeopathic treatment is that it has negligible side effects

Removing a portion of the brain. The most common type of epilepsy surgery is the removal of the portion of the brain usually about the size of a golf ball that’s causing the seizures. This type of surgery — called resective surgery can remove a lobe, a portion of a lobe or a lesion and is highly successful

The role of immunity and inflammation appears to be an integral part of the pathogenic processes associated with some seizures, particularly with refractory epilepsy. Prompt treatment with immunotherapy may lead to better outcomes. Immune treatment options for treatment of epilepsy include therapies such as corticosteroids, immunoglobulin’s, plasmapheresis, or steroid-sparing drugs such as azathioprine

Emotional distress is common in people with epilepsy (PWE) for which efficacious interventions are required. Developing evidence-based treatments should be based on testable models of the psychological mechanisms maintaining psychopathology. The Self-Regulatory Executive Function (S-REF) model proposes that maladaptive metacognitive beliefs and processes are central to the development and maintenance of emotional distress. Although preliminary support exists for the role of metacognitive beliefs in emotional distress in PWE, their role has yet to be tested when controlling for the contribution made by illness perceptions.

The interest in cannabis-based products for the treatment of refractory epilepsy has skyrocketed in recent years. Treatment-resistant epilepsy (TRE) affects 30% of epilepsy patients and is associated with severe morbidity and increased mortality. Cannabis-based therapies have been used to treat epilepsy for millennia, but only in the last few years have we begun to collect data from adequately powered placebo-controlled, randomized trials (RCTs) with cannabidiol (CBD), a cannabis derivative.

Cognitive disorders are common in patients with epilepsy. Their aetiology is multifactorial, being affected by the type and location of the epileptogenic lesion, epileptic syndrome, type of seizures, age of onset, frequency and severity. Timely diagnosis and treatment can help to reduce their impact on the patient's quality of life.

Doctors have developed when an individual experience a seizure for the first time doctors advices him for EEG and observes for abnormality in the of  EEG these tests differentiate patient from epileptic to non- epileptic .Research suggests that patients are only suggested to medicated for epilepsy only after their  occurrence of second seizure. Many non-epileptic patients experience an unusual brain activity so; it is advised to record EEG while sleeping is preferable. Brain scan like CT- SCAN are used.

Majorly epilepsy is treated with antiepileptic drugs primarily first line drugs like carbamazepine, valproate, phenytoin, carbazepine whereas, second generation include zonisamide and lacosamide are showing good efficacy with low adverse effects. Ethosuximide is majorly used for primary treatment. Diazepam is now available as rectal gel so that can be applied by family members for prolonged seizures. Drug combination sometimes lead to adverse effects like fatigue and loss of appetite so, combinations are often replaced by monotherapy unless monotherapy achieves desired results. When medication doesn’t achieve the required targets doctor can sometimes suggest for surgery 64% cases showed seizure free cases who undergone surgery.

The globamarket for Antiepileptic drugs is driven by advancement in drugs modification. Over the past several periods, the number of available Antiepileptic drugs has more than doubled. , many of the presently available Antiepileptic drugs have basics pharmacokinetics and more small effects on liver metabolism that converts into a lower rate of side effects, The antiepileptic drug market is threatened by generic competition, which has risen dramatically in the face of patent expirations among various major branded Antiepileptic drugs. These are the major restraints for the Global antiepileptic drugs market.l 

According to WHO, It is estimated that every year nearly 2.4 million people are diagnosed with Epilepsy and there are 4 to 5 in a group of 1000 people with active Epilepsy. Nearly 80% of the individuals with Epilepsy is found in developing regions, Epilepsy represents 0.6%, of the worldwide weight of sickness.