Naoto Hoshi
University of California, USA
Title: Palmitoylation of neural proteins might be a link between lipid metabolism and anticonvulsant action
Biography
Biography: Naoto Hoshi
Abstract
We recently found that valproic acid suppresses palmitoylation of neural proteins including AKAP5 (AKAP79/150). Reduced AKAP5 palmitoylation disrupted regulation of the M-current, which is generated by neural Kv7 channel family. Various neurotransmitters that activate Gq-coupled receptors suppress M-current and increase neuronal excitability. We show that palmitoylation is required for receptor-induced M-current supprssion. Similar disruption of M-current suppression was observed by inhibition of acyl-CoA synthetase. These results might fill in a gap between lipid metabolism and its anti-convalsant action.